Edwin De Los Santos has two losses against two opponents on his boxing record. For a list of Santos's best fights, refer to "Best fights of Edwin De Los Santos".
On November 16, 2023 Edwin De Los Santos fought Shakur Stevenson in a lightweight world-title fight for the WBC title. Santos was 24 years old and with a record of 16-2 (14), and Stevenson was 26 years old and with a record of 20-0 (10). Santos lost the fight via 12-round unanimous decision.
On January 7, 2022 Edwin De Los Santos faced off against William Foster III at age 22. He was coming in with a record of 13-1 (12). Santos lost the fight via 8-round split decision.
