Here is a list of Santos's best fights. For a list of Santos's losses, refer to "Edwin De Los Santos Losses".
On July 8, 2023 Edwin De Los Santos faced off against Joseph Adorno in a lightweight bout at age 23. He was coming in with a record of 16-1 (14), and Adorno was 24 years old and with a record of 17-2-2 (14). Santos won the fight via 10-round unanimous decision.
On September 4, 2022 Edwin De Los Santos faced off against Jose Valenzuela in a lightweight bout at age 22. He was coming in with a record of 15-1 (14), and Valenzuela was 23 years old and with a record of 12-0 (8). Santos stopped Jose Valenzuela via KO.
On May 25, 2019 Edwin De Los Santos faced off against Antoni Armas in a super-featherweight bout at age 19. He was coming in with a record of 8-0 (7). Santos stopped Antoni Armas via TKO.
On February 22, 2020 Edwin De Los Santos faced off against Juan Alberto Garcia Perez in a lightweight bout at age 20. He was coming in with a record of 10-0 (9). Santos stopped Juan Alberto Garcia Perez via TKO.
On March 12, 2021 Edwin De Los Santos faced off against Luis Montano Alvarez in a super-featherweight bout at age 21. He was coming in with a record of 12-0 (11). Santos stopped Luis Montano Alvarez via TKO.
