Darren Barker has two losses against two opponents on his boxing record. For a list of Barker's best fights, refer to "Best fights of Darren Barker".
On December 7, 2013 Darren Barker met Felix Sturm in a middleweight (IBF) world-title defense fight. Barker was 31 years old and with a record of 26-2 (16), and Sturm was 34 years old and with a record of 38-3-2 (17). Barker lost the fight via 2nd-round TKO and lost the title.
On October 1, 2011 Darren Barker fought Sergio Martínez in a middleweight world-title fight for Martínez' The Ring title. Barker was 29 years old and with a record of 23-1 (14), and Martínez was 36 years old and with a record of 47-2-2 (26). Barker lost the fight via 11th-round KO.