Buster Mathis Jr. has two losses against two opponents on his boxing record. For a list of Mathis Jr.'s best fights, refer to "Best fights of Buster Mathis Jr.".
On November 1, 1996 Buster Mathis Jr. faced off against Lou Savarese in a heavyweight bout at age 26. He was coming in with a record of 21-2 (7), and Savarese was 31 years old and with a record of 35-0 (29). Mathis Jr. lost the fight via 7th-round TKO.
On December 16, 1995 Buster Mathis Jr. faced off against Mike Tyson at age 25. He was coming in with a record of 20-1 (6), and Tyson was 29 years old and with a record of 42-1 (36). Mathis Jr. lost the fight via 3rd-round KO.
