Buster Mathis has four losses against four opponents on his boxing record. For a list of Mathis's best fights, refer to "Best fights of Buster Mathis".
On September 29, 1972 Buster Mathis faced off against Ron Lyle at age 29. He was coming in with a record of 30-4 (21), and Lyle was 31 years old and with a record of 16-0 (14). Mathis lost the fight via 2nd-round KO.
On November 17, 1971 Buster Mathis faced off against Muhammad Ali in a heavyweight bout at age 28. He was coming in with a record of 29-3 (20), and Ali was 29 years old and with a record of 32-1 (26). Mathis lost the fight via 12-round unanimous decision.
On March 24, 1969 Buster Mathis faced off against Jerry Quarry at age 25. He was coming in with a record of 29-2 (20), and Quarry was 23 years old and with a record of 30-2-4 (18). Mathis lost the fight via 12-round unanimous decision.
On March 4, 1968 Buster Mathis faced off against Joe Frazier in a heavyweight bout at age 24. He was coming in with a record of 23-1 (17), and Frazier was 24 years old and with a record of 19-0 (17). Mathis lost the fight via 11th-round TKO.
