Here is a list of Mathis's best fights. For a list of Mathis's losses, refer to "Buster Mathis Losses".
On February 3, 1969 Buster Mathis faced off against George Chuvalo at age 25. He was coming in with a record of 29-1 (20), and Chuvalo was 31 years old and with a record of 53-14-2 (45). Mathis won the fight via 12-round unanimous decision.