Andy Lee has three losses against three opponents on his boxing record. For a list of Lee's best fights, refer to "Best fights of Andy Lee".
On December 19, 2015 Andy Lee met Billy Joe Saunders in a middleweight (WBO) world-title defense fight. Lee was 31 years old and with a record of 34-3-1 (24), and Saunders was 26 years old and with a record of 22-0 (12). Lee lost the fight via 12-round majority decision and lost the title.
On June 16, 2012 Andy Lee fought Julio César Chávez Jr. in a middleweight world-title fight for Chávez Jr.'s WBC title. Lee was 28 years old and with a record of 28-2 (20), and Chávez Jr. was 26 years old and with a record of 45-0-1 (31). Lee lost the fight via 7th-round TKO.
On March 21, 2008 Andy Lee faced off against Brian Vera at age 23. He was coming in with a record of 15-1 (12). Lee lost the fight via 7th-round TKO.