Alfredo Santiago has two losses against two opponents on his boxing record. For a list of Santiago's best fights, refer to "Best fights of Alfredo Santiago".
On May 21, 2021 Alfredo Santiago faced off against Ricardo Nunez in a lightweight bout at age 26. He was coming in with a record of 13-2 (5), and Nunez was 27 years old and with a record of 21-3 (19). Santiago lost the fight via 9th-round TKO.
On November 9, 2019 Alfredo Santiago fought Devin Haney in a lightweight world-title fight for Haney's WBC title. Santiago was 24 years old and with a record of 12-1 (4), and Haney was 20 years old and with a record of 23-0 (15). Santiago lost the fight via 12-round unanimous decision.
