Here is a list of Santiago's best fights. For a list of Santiago's losses, refer to "Alfredo Santiago Losses".
On December 1, 2018 Alfredo Santiago faced off against Jonathan Victor Barros in a lightweight bout at age 24. He was coming in with a record of 11-0 (3), and Barros was 34 years old and with a record of 41-6-1 (22). Santiago won the fight via 10-round unanimous decision.
On March 1, 2025 Alfredo Santiago faced off against Javier Fortuna in a super-lightweight bout at age 30. He was coming in with a record of 17-2 (8), and Fortuna was 35 years old and with a record of 39-5-1 (28). Santiago stopped Javier Fortuna via TKO.
On December 17, 2020 Alfredo Santiago faced off against Tony Gomez in a lightweight bout at age 26. He was coming in with a record of 13-1 (5). Santiago stopped Tony Gomez via KO.
On November 9, 2024 Alfredo Santiago faced off against Pedro Campa in a super-lightweight bout at age 29. He was coming in with a record of 16-2 (7). Santiago stopped Pedro Campa via TKO.
