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Edwin De Los Santos has had a total of two losses in his professional boxing career so far — one of them in a title bout and one in a non-title bout. He suffered his first loss against William Foster III via 8 round split decision on January 7, 2022, which ended his 13-fight win streak. He has never been stopped, both his losses came via decision.
Shakur Stevenson and William Foster III are the two boxers who have beaten Santos.
This is the first loss in Edwin De Los Santos' career. Santos lost to William Foster III via 8 round split decision on in a non-title bout. He was 22 years old with a record of 13-0.
On Santos lost to American boxer Shakur Stevenson via 12 round unanimous decision. He and Stevenson were fighting for the vacant lightweight WBC title. He was 24 years old with a record of 16-1. Stevenson was 26 years old with a record of 20-0.