Here is a list of Vázquez Jr.'s best fights. For a list of Vázquez Jr.'s losses, refer to "Wilfredo Vázquez Jr. Losses".
On May 29, 2010 Wilfredo Vázquez Jr. met Zsolt Bedák in a super-bantamweight (WBO) world-title defense fight. Vázquez Jr. was 25 years old and with a record of 19-0-1 (16), and Bedák was 26 years old and with a record of 15-0 (5). Vázquez Jr. stopped Zsolt Bedák via 10th-round TKO and successfully defended his title.
On October 6, 2012 Wilfredo Vázquez Jr. faced off against Jonathan Oquendo in a super-bantamweight bout at age 28. He was coming in with a record of 22-2-1 (19), and Oquendo was 29 years old and with a record of 22-2 (15). Vázquez Jr. stopped Jonathan Oquendo via TKO.
On June 16, 2018 Wilfredo Vázquez Jr. faced off against Cristian Mijares at age 33. He was coming in with a record of 25-7-1 (20), and Mijares was 36 years old and with a record of 59-8-2 (27). Vázquez Jr. stopped Cristian Mijares via KO.
On October 29, 2011 Wilfredo Vázquez Jr. faced off against Roberto Carlos Leyva at age 27. He was coming in with a record of 21-1-1 (18), and Leyva was 32 years old and with a record of 27-14-1 (21). Vázquez Jr. stopped Roberto Carlos Leyva via KO.
On July 17, 2009 Wilfredo Vázquez Jr. faced off against Cecilio Santos in a super-bantamweight bout at age 25. He was coming in with a record of 16-0-1 (13). Vázquez Jr. stopped Cecilio Santos via KO.