Paul Williams has two losses against two opponents on his boxing record. For a list of Williams's best fights, refer to "Best fights of Paul Williams".
On November 20, 2010 Paul Williams fought Sergio Martínez in a middleweight world-title fight for Martínez' WBC and The Ring titles. Williams was 29 years old and with a record of 39-2 (27), and Martínez was 35 years old and with a record of 45-2-2 (24). Williams lost the fight via 2nd-round KO.
On February 9, 2008 Paul Williams met Carlos Quintana in a welterweight (WBO) world-title defense fight. Williams was 26 years old and with a record of 33-1 (24), and Quintana was 31 years old and with a record of 24-1 (19). Williams lost the fight via 12-round unanimous decision and lost the title.