Here is a list of Spadafora's best fights. For a list of Spadafora's losses, refer to "Paul Spadafora Losses".
On March 3, 2000 Paul Spadafora met Victoriano Sosa in a lightweight (IBF) world-title defense fight. Spadafora was 24 years old and with a record of 29-0 (14), and Sosa was 25 years old and with a record of 24-1-1 (19). Spadafora won the fight via 12-round unanimous decision and successfully defended his title.
On March 9, 2002 Paul Spadafora met Angel Manfredy in a lightweight (IBF) world-title defense fight. Spadafora was 26 years old and with a record of 35-0 (14), and Manfredy was 27 years old and with a record of 39-5-1 (29). Spadafora won the fight via 12-round unanimous decision and successfully defended his title.
On July 11, 2014 Paul Spadafora faced off against Héctor Velázquez at age 38. He was coming in with a record of 49-1-1 (19), and Velázquez was 39 years old and with a record of 55-21-3 (37). Spadafora won the fight via 8-round unanimous decision.