Moruti Mthalane has three losses against three opponents on his boxing record. For a list of Mthalane's best fights, refer to "Best fights of Moruti Mthalane".
On April 30, 2021 Moruti Mthalane met Sunny Edwards in a flyweight (IBF) world-title defense fight. Mthalane was 38 years old and with a record of 39-3 (26), and Edwards was 25 years old and with a record of 15-0 (4). Mthalane lost the fight via 12-round unanimous decision and lost the title.
On November 1, 2008 Moruti Mthalane fought Nonito Donaire in a flyweight world-title fight for Donaire's IBF title. Mthalane was 26 years old and with a record of 23-2 (15), and Donaire was 25 years old and with a record of 19-1 (12). Mthalane lost the fight via 6th-round TKO.
On September 24, 2004 Moruti Mthalane faced off against Nkqubela Gwazela in a flyweight bout at age 21. He was coming in with a record of 14-1 (8). Mthalane lost the fight via 10th-round TKO.
