Lucas Matthysse has five losses against five opponents on his boxing record. For a list of Matthysse's best fights, refer to "Best fights of Lucas Matthysse".
On July 15, 2018 Lucas Matthysse met Manny Pacquiao in a welterweight (WBA (Regular)) world-title defense fight. Matthysse was 35 years old and with a record of 39-5 (36), and Pacquiao was 39 years old and with a record of 59-7-2 (38). Matthysse lost the fight via 7th-round TKO and lost the title.
On October 3, 2015 Lucas Matthysse fought Viktor Postol in a super-lightweight world-title fight for the WBC title. Matthysse was 33 years old and with a record of 37-4 (34), and Postol was 31 years old and with a record of 27-0 (11). Matthysse lost the fight via 10th-round KO.
On September 14, 2013 Lucas Matthysse fought Danny García in a super-lightweight world-title fight for the WBA (Super), WBC and The Ring titles. Matthysse was 30 years old and with a record of 34-3 (32), and García was 25 years old and with a record of 26-0 (16). Matthysse lost the fight via 12-round unanimous decision.
On June 25, 2011 Lucas Matthysse faced off against Devon Alexander at age 28. He was coming in with a record of 28-2 (26), and Alexander was 24 years old and with a record of 21-1 (13). Matthysse lost the fight via 10-round split decision.
On November 6, 2010 Lucas Matthysse faced off against Zab Judah in a super-lightweight bout at age 28. He was coming in with a record of 27-1 (25), and Judah was 33 years old and with a record of 39-6 (27). Matthysse lost the fight via 12-round split decision.