Jose Zepeda has five losses against five opponents on his boxing record. For a list of Zepeda's best fights, refer to "Best fights of Jose Zepeda".
On March 23, 2024 Jose Zepeda faced off against Dalton Smith in a super-lightweight bout at age 34. He was coming in with a record of 37-5 (28), and Smith was 27 years old and with a record of 15-0 (11). Zepeda lost the fight via 5th-round KO.
On September 23, 2023 Jose Zepeda faced off against Richardson Hitchins in a super-lightweight bout at age 34. He was coming in with a record of 37-4 (28), and Hitchins was 25 years old and with a record of 16-0 (7). Zepeda lost the fight via 12-round unanimous decision.
On November 26, 2022 Jose Zepeda faced off against Regis Prograis in a super-lightweight bout at age 33. He was coming in with a record of 36-3 (28), and Prograis was 33 years old and with a record of 27-1 (23). Zepeda lost the fight via 11th-round KO.
On February 10, 2019 Jose Zepeda fought José Ramírez in a super-lightweight world-title fight for Ramírez' WBC title. Zepeda was 29 years old and with a record of 30-2 (25), and Ramírez was 26 years old and with a record of 23-0 (16). Zepeda lost the fight via 12-round majority decision.
On July 11, 2015 Jose Zepeda fought Terry Flanagan in a lightweight world-title fight for the WBO title. Zepeda was 26 years old and with a record of 23-1 (20), and Flanagan was 26 years old and with a record of 27-0 (10). Zepeda lost the fight via 2nd-round retirement.