José Ramírez has three losses against three opponents on his boxing record. For a list of Ramírez's best fights, refer to "Best fights of José Ramírez".
On May 2, 2025 José Ramírez faced off against Devin Haney in a super-lightweight bout at age 32. He was coming in with a record of 29-3 (18), and Haney was 26 years old and with a record of 31-0 (15). Ramírez lost the fight via 12-round unanimous decision.
On November 16, 2024 José Ramírez faced off against Arnold Barboza Jr. in a super-lightweight bout at age 32. He was coming in with a record of 29-2 (18), and Barboza Jr. was 32 years old and with a record of 30-0 (11). Ramírez lost the fight via 10-round unanimous decision.
On May 22, 2021 José Ramírez, the WBC and WBO champion, met Josh Taylor, the WBA (Super), IBF and The Ring champion, in a super-lightweight world-title unification fight. Ramírez was 28 years old and with a record of 26-1 (17), and Taylor was 30 years old and with a record of 17-0 (13). Ramírez lost the fight via 12-round unanimous decision and lost his titles.