Jeffrey Mathebula has five losses against five opponents on his boxing record. For a list of Mathebula's best fights, refer to "Best fights of Jeffrey Mathebula".
On December 21, 2013 Jeffrey Mathebula fought Kiko Martínez in a super-bantamweight world-title fight for Martínez' IBF title. Mathebula was 34 years old and with a record of 27-5-2 (14), and Martínez was 27 years old and with a record of 29-4 (21). Mathebula lost the fight via 9th-round KO.
On July 7, 2012 Jeffrey Mathebula, the IBF champion, met Nonito Donaire, the WBO champion, in a super-bantamweight world-title unification fight. Mathebula was 33 years old and with a record of 26-4-2 (14), and Donaire was 29 years old and with a record of 28-1 (18). Mathebula lost the fight via 12-round unanimous decision and lost his title.
On September 1, 2010 Jeffrey Mathebula faced off against Takalani Ndlovu at age 31. He was coming in with a record of 23-3-2 (13). Mathebula lost the fight via 12-round split decision.
On April 30, 2009 Jeffrey Mathebula fought Celestino Caballero in a super-bantamweight world-title fight for Caballero's WBA (Super) and IBF titles. Mathebula was 29 years old and with a record of 22-2-2 (12), and Caballero was 32 years old and with a record of 31-2 (22). Mathebula lost the fight via 12-round split decision.
On September 30, 2003 Jeffrey Mathebula faced off against Thomas Mashaba in a super-bantamweight bout at age 24. He was coming in with a record of 13-1-1 (9). Mathebula lost the fight via 6th-round TKO.