Emmanuel Rodriguez has three losses against three opponents on his boxing record. For a list of Rodriguez's best fights, refer to "Best fights of Emmanuel Rodriguez".
On May 4, 2024 Emmanuel Rodriguez met Ryosuke Nishida in a bantamweight (IBF) world-title defense fight. Rodriguez was 31 years old and with a record of 22-3 (13), and Nishida was 27 years old and with a record of 8-0 (1). Rodriguez lost the fight via 12-round unanimous decision and lost the title.
On December 19, 2020 Emmanuel Rodriguez fought Reymart Gaballo in a bantamweight world-title fight for the WBC title. Rodriguez was 28 years old and with a record of 19-2 (12), and Gaballo was 24 years old and with a record of 23-0 (20). Rodriguez lost the fight via 12-round split decision.
On May 18, 2019 Emmanuel Rodriguez, the IBF champion, met Naoya Inoue, the The Ring champion, in a bantamweight world-title unification fight. Rodriguez was 26 years old and with a record of 19-1 (12), and Inoue was 26 years old and with a record of 17-0 (15). Rodriguez lost the fight via 2nd-round KO and lost his title.