Here is a list of Rodríguez's best fights. For a list of Rodríguez's losses, refer to "Edwin Rodríguez Losses".
On March 30, 2013 Edwin Rodríguez faced off against Ezequiel Maderna in a super-middleweight bout at age 27. He was coming in with a record of 23-0 (14), and Maderna was 26 years old and with a record of 19-0 (13). Rodríguez won the fight via 10-round unanimous decision.
On November 13, 2015 Edwin Rodríguez faced off against Michael Seals in a super-middleweight bout at age 30. He was coming in with a record of 28-1 (18), and Seals was 33 years old and with a record of 19-0 (14). Rodríguez stopped Michael Seals via TKO.
On October 3, 2009 Edwin Rodríguez faced off against Darnell Boone at age 24. He was coming in with a record of 12-0 (8), and Boone was 29 years old and with a record of 16-12-2 (6). Rodríguez won the fight via 8-round unanimous decision.
On July 18, 2017 Edwin Rodríguez faced off against Melvin Russell in a super-middleweight bout at age 32. He was coming in with a record of 29-2 (19), and Russell was 38 years old and with a record of 10-1-2 (6). Rodríguez stopped Melvin Russell via TKO.