David Picasso has one loss against one opponent on his boxing record. For a list of Picasso's best fights, refer to "Best fights of David Picasso".
On December 27, 2025 David Picasso fought Naoya Inoue in a super-bantamweight world-title fight for Inoue's WBA (Super), WBC, IBF, WBO and The Ring titles. Picasso was 25 years old and with a record of 32-1-1 (17), and Inoue was 32 years old and with a record of 31-0 (27). Picasso lost the fight via 12-round unanimous decision.