Chris Billam-Smith has two losses against two opponents on his boxing record. For a list of Billam-Smith's best fights, refer to "Best fights of Chris Billam-Smith".
On November 16, 2024 Chris Billam-Smith, the WBO champion, met Gilberto Ramírez, the WBA champion, in a cruiserweight world-title unification fight. Billam-Smith was 34 years old and with a record of 20-2 (13), and Ramírez was 33 years old and with a record of 46-1 (30). Billam-Smith lost the fight via 12-round unanimous decision and lost his title.
On July 20, 2019 Chris Billam-Smith faced off against Richard Riakporhe in a cruiserweight bout at age 28. He was coming in with a record of 9-1 (8), and Riakporhe was 29 years old and with a record of 9-0 (8). Billam-Smith lost the fight via 10-round split decision.