Brian Castaño has one loss against one opponent on his boxing record. For a list of Castaño's best fights, refer to "Best fights of Brian Castaño".
On May 14, 2022 Brian Castaño, the WBO champion, met Jermell Charlo, the WBA (Super), WBC, IBF and The Ring champion, in a super-welterweight world-title unification fight. Castaño was 32 years old and with a record of 17-1-2 (12), and Charlo was 31 years old and with a record of 34-1-1 (18). Castaño lost the fight via 10th-round KO and lost his title.