Antonio Nieves has four losses against four opponents on his boxing record. For a list of Nieves's best fights, refer to "Best fights of Antonio Nieves".
On October 29, 2022 Antonio Nieves faced off against Alexandro Santiago at age 35. He was coming in with a record of 20-4-2 (11), and Santiago was 26 years old and with a record of 26-3-5 (13). Nieves lost the fight via 7th-round retirement.
On October 26, 2019 Antonio Nieves faced off against Joshua Greer Jr. in a bantamweight bout at age 32. He was coming in with a record of 19-3-2 (11), and Greer Jr. was 25 years old and with a record of 21-1-1 (12). Nieves lost the fight via 10-round unanimous decision.
On September 9, 2017 Antonio Nieves fought Naoya Inoue in a super-flyweight world-title fight for Inoue's WBO title. Nieves was 30 years old and with a record of 17-2-2 (9), and Inoue was 24 years old and with a record of 13-0 (11). Nieves lost the fight via 6th-round retirement.
On March 10, 2017 Antonio Nieves faced off against Nikolai Potapov in a bantamweight bout at age 29. He was coming in with a record of 17-1-2 (9), and Potapov was 27 years old and with a record of 16-0-1 (8). Nieves lost the fight via 10-round split decision.
