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Alfredo Santiago has had a total of two losses in his professional boxing career so far — one of them in a title bout and one in a non-title bout. He suffered his first loss against Devin Haney via 12 round unanimous decision on November 9, 2019, which ended his 12-fight win streak. He has been stopped once and lost once via decision.
Ricardo Nunez and Devin Haney are the two boxers who have beaten Santiago.
This is the first loss in Alfredo Santiago's career. Santiago lost to American boxer Devin Haney via 12 round unanimous decision on . He was fighting for Haney's lightweight WBC title, he was 24 years old with a record of 12-0. Haney was 20 years old with a record of 23-0.
On Santiago lost to Panamanian boxer Ricardo Nunez via 9th round TKO in a non-title bout. He was 26 years old with a record of 13-1. Nunez was 27 years old with a record of 21-3.