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Yoshihiro Kamegai had a total of five losses in his professional boxing career — one of them in a title bout and four in non-title bouts. He suffered his first loss against Johan Perez via 10 round unanimous decision on June 8, 2013, which ended his 22-fight win streak. He has never been stopped, all his losses came via decision.
Greg Vendetti, Miguel Cotto, Alfonso Gómez, Robert Guerrero, and Johan Perez are the five boxers who have beaten Kamegai.
This is the first loss in Yoshihiro Kamegai's career. Kamegai lost to Johan Perez via 10 round unanimous decision on in a non-title bout. He was 30 years old with a record of 22-0-1.
On Kamegai lost to American boxer Robert Guerrero via 12 round unanimous decision in a non-title bout. He was 31 years old with a record of 24-1-1. Guerrero was also 31 years old, with a record of 31-2-1.
On Kamegai lost to Mexican boxer Alfonso Gómez via 10 round unanimous decision in a non-title bout. He was 32 years old with a record of 25-2-1. Gómez was 34 years old with a record of 24-6-2.
On Kamegai lost to Puerto Rican boxer Miguel Cotto via 12 round unanimous decision. He and Cotto were fighting for the vacant super-welterweight WBO title. He was 34 years old with a record of 27-3-2. Cotto was 36 years old with a record of 40-5.
On Kamegai lost to Greg Vendetti via 10 round unanimous decision in a non-title bout. He was 35 years old with a record of 27-4-2.