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Vanes Martirosyan had a total of four losses in his professional boxing career — three of them in title bouts and one in a non-title bout. He suffered his first loss against Demetrius Andrade via 12 round split decision on November 9, 2013, which ended his 33-fight win streak. He has been stopped once and lost three times via decision.
Gennady Golovkin, Erislandy Lara, Jermell Charlo, and Demetrius Andrade are the four boxers who have beaten Martirosyan.
This is the first loss in Vanes Martirosyan's career. Martirosyan lost to American boxer Demetrius Andrade via 12 round split decision on . He and Andrade were fighting for the vacant super-welterweight WBO title. He was 27 years old with a record of 33-0-1. Andrade was 25 years old with a record of 19-0.
On Martirosyan lost to American boxer Jermell Charlo via 10 round unanimous decision in a non-title bout. He was 28 years old with a record of 35-1-1. Charlo was 24 years old with a record of 25-0.
On Martirosyan lost to American boxer Erislandy Lara in a rematch via 12 round unanimous decision. He was fighting for Lara's super-welterweight WBA title, he was 30 years old with a record of 36-2-1. Lara was 33 years old with a record of 22-2-2.
On Martirosyan lost to Kazakhstani boxer Gennady Golovkin via 2nd round KO. He was fighting for Golovkin's middleweight WBA (Super) and WBC titles, he was 32 years old with a record of 36-3-1. Golovkin was 36 years old with a record of 37-0-1.