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Sergiy Derevyanchenko has had a total of five losses in his professional boxing career so far — three of them in title bouts and two in non-title bouts. He suffered his first loss against Daniel Jacobs via 12 round split decision on October 27, 2018, which ended his 12-fight win streak. He has never been stopped, all his losses came via decision.
Jaime Munguía, Carlos Adames, Jermall Charlo, Gennady Golovkin, and Daniel Jacobs are the five boxers who have beaten Derevyanchenko.
This is the first loss in Sergiy Derevyanchenko's career. Derevyanchenko lost to American boxer Daniel Jacobs via 12 round split decision on . He and Jacobs were fighting for the vacant middleweight IBF title. He was 32 years old with a record of 12-0. Jacobs was 31 years old with a record of 34-2.
On Derevyanchenko lost to Kazakhstani boxer Gennady Golovkin via 12 round unanimous decision. He and Golovkin were fighting for the vacant middleweight IBF title. He was 33 years old with a record of 13-1. Golovkin was 37 years old with a record of 39-1-1.
On Derevyanchenko lost to American boxer Jermall Charlo via 12 round unanimous decision. He was fighting for Charlo's middleweight WBC title, he was 34 years old with a record of 13-2. Charlo was 30 years old with a record of 30-0.
On Derevyanchenko lost to Dominican boxer Carlos Adames via 10 round majority decision in a non-title bout. He was 36 years old with a record of 13-3. Adames was 27 years old with a record of 20-1.
On Derevyanchenko lost to Mexican boxer Jaime Munguía via 12 round unanimous decision in a non-title bout. He was 37 years old with a record of 14-4. Munguía was 26 years old with a record of 41-0.