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Mikkel Kessler had a total of three losses in his professional boxing career — all of them in title bouts. He suffered his first loss against Joe Calzaghe via 12 round unanimous decision on November 3, 2007, which ended his 39-fight win streak. He has never been stopped, all his losses came via decision.
Carl Froch, Andre Ward, and Joe Calzaghe are the three boxers who have beaten Kessler.
This is the first loss in Mikkel Kessler's career. Kessler lost to Welsh boxer Joe Calzaghe via 12 round unanimous decision on . He was defending his super-middleweight WBA (Super) and WBC titles, and fighting for Calzaghe's super-middleweight WBO and The Ring titles, he was 28 years old with a record of 39-0. Calzaghe was 35 years old with a record of 43-0.
On Kessler lost to American boxer Andre Ward via 11 round technical decision. He was defending his super-middleweight WBA title, and fighting for Ward's super-middleweight WBA title, he was 30 years old with a record of 42-1. Ward was 25 years old with a record of 20-0.
On Kessler lost to British boxer Carl Froch in a rematch via 12 round unanimous decision. He was defending his super-middleweight WBA (Regular) title, and fighting for Froch's super-middleweight IBF title, he was 34 years old with a record of 46-2. Froch was 35 years old with a record of 30-2.