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James Kirkland had a total of three losses in his professional boxing career — all of them in non-title bouts. He suffered his first loss against Nobuhiro Ishida via 1st round TKO on April 9, 2011, which ended his 27-fight win streak. All of Kirkland's losses came via stoppage.
Juan Macias Montiel, Canelo Álvarez, and Nobuhiro Ishida are the three boxers who have beaten Kirkland.
This is the first loss in James Kirkland's career. Kirkland lost to Japanese boxer Nobuhiro Ishida via 1st round TKO on in a non-title bout. He was 27 years old with a record of 27-0. Ishida was 35 years old with a record of 22-6-2.
On Kirkland lost to Mexican boxer Canelo Álvarez via 3rd round KO in a non-title bout. He was 31 years old with a record of 32-1. Canelo was 24 years old with a record of 44-1-1.
On Kirkland lost to Mexican boxer Juan Macias Montiel via 1st round KO in a non-title bout. He was 36 years old with a record of 34-2. Montiel was 26 years old with a record of 21-4-2.