Yuriorkis Gamboa has five losses against five opponents on his boxing record. For a list of Gamboa's best fights, refer to "Best fights of Yuriorkis Gamboa".
On April 16, 2022 Yuriorkis Gamboa faced off against Isaac Cruz in a lightweight bout at age 40. He was coming in with a record of 30-5 (18), and Cruz was 23 years old and with a record of 22-2-1 (15). Gamboa lost the fight via 5th-round TKO.
On November 7, 2020 Yuriorkis Gamboa fought Devin Haney in a lightweight world-title fight for Haney's WBC title. Gamboa was 38 years old and with a record of 30-4 (18), and Haney was 21 years old and with a record of 24-0 (15). Gamboa lost the fight via 12-round unanimous decision.
On December 28, 2019 Yuriorkis Gamboa fought Gervonta Davis in a lightweight world-title fight for the WBA (Regular) title. Gamboa was 38 years old and with a record of 30-3 (18), and Davis was 25 years old and with a record of 22-0 (21). Gamboa lost the fight via 12th-round TKO.
On May 5, 2017 Yuriorkis Gamboa faced off against Robinson Castellanos in a lightweight bout at age 35. He was coming in with a record of 26-2 (17), and Castellanos was 35 years old and with a record of 23-12 (13). Gamboa lost the fight via 7th-round retirement.
On June 28, 2014 Yuriorkis Gamboa fought Terence Crawford in a lightweight world-title fight for Crawford's WBO title. Gamboa was 32 years old and with a record of 23-1 (16), and Crawford was 26 years old and with a record of 23-0 (16). Gamboa lost the fight via 9th-round KO.