Yoshihiro Kamegai has five losses against five opponents on his boxing record. For a list of Kamegai's best fights, refer to "Best fights of Yoshihiro Kamegai".
On August 17, 2018 Yoshihiro Kamegai faced off against Greg Vendetti at age 35. He was coming in with a record of 27-5-2 (24). Kamegai lost the fight via 10-round unanimous decision.
On August 26, 2017 Yoshihiro Kamegai fought Miguel Cotto in a super-welterweight world-title fight for the WBO title. Kamegai was 34 years old and with a record of 27-4-2 (24), and Cotto was 36 years old and with a record of 40-5 (33). Kamegai lost the fight via 12-round unanimous decision.
On March 20, 2015 Yoshihiro Kamegai faced off against Alfonso Gómez at age 32. He was coming in with a record of 25-3-1 (22), and Gómez was 34 years old and with a record of 24-6-2 (12). Kamegai lost the fight via 10-round unanimous decision.
On June 21, 2014 Yoshihiro Kamegai faced off against Robert Guerrero at age 31. He was coming in with a record of 24-2-1 (21), and Guerrero was 31 years old and with a record of 31-2-1 (18). Kamegai lost the fight via 12-round unanimous decision.
On June 8, 2013 Yoshihiro Kamegai faced off against Johan Perez in a welterweight bout at age 30. He was coming in with a record of 22-1-1 (19). Kamegai lost the fight via 10-round unanimous decision.