Willie Monroe Jr. has three losses against three opponents on his boxing record. For a list of Monroe Jr.'s best fights, refer to "Best fights of Willie Monroe Jr.".
On September 16, 2017 Willie Monroe Jr. fought Billy Joe Saunders in a middleweight world-title fight for Saunders' WBO title. Monroe Jr. was 30 years old and with a record of 21-3 (6), and Saunders was 28 years old and with a record of 24-0 (12). Monroe Jr. lost the fight via 12-round unanimous decision.
On May 16, 2015 Willie Monroe Jr. fought Gennadiy Golovkin in a middleweight world-title fight for Golovkin's WBA (Super) and WBC titles. Monroe Jr. was 28 years old and with a record of 19-2 (6), and Golovkin was 33 years old and with a record of 32-0 (29). Monroe Jr. lost the fight via 6th-round TKO.
On March 29, 2011 Willie Monroe Jr. faced off against Darnell Boone at age 24. He was coming in with a record of 10-1 (4), and Boone was 31 years old and with a record of 17-17-3 (7). Monroe Jr. lost the fight via 8-round split decision.