Wayne Braithwaite has six losses against six opponents on his boxing record. For a list of Braithwaite's best fights, refer to "Best fights of Wayne Braithwaite".
On October 26, 2012 Wayne Braithwaite faced off against Shawn Corbin in a cruiserweight bout at age 37. He was coming in with a record of 24-6 (20). Braithwaite lost the fight via 12-round unanimous decision.
On February 25, 2012 Wayne Braithwaite faced off against Shawn Cox in a heavyweight bout at age 36. He was coming in with a record of 24-5 (20). Braithwaite lost the fight via 1st-round KO.
On July 11, 2009 Wayne Braithwaite faced off against Steve Cunningham at age 33. He was coming in with a record of 23-4 (19), and Cunningham was 32 years old and with a record of 21-2 (11). Braithwaite lost the fight via 12-round unanimous decision.
On July 21, 2007 Wayne Braithwaite fought Enzo Maccarinelli in a cruiserweight world-title fight for Maccarinelli's WBO title. Braithwaite was 31 years old and with a record of 22-3 (18), and Maccarinelli was 26 years old and with a record of 26-1 (20). Braithwaite lost the fight via 12-round unanimous decision.
On September 3, 2005 Wayne Braithwaite faced off against Guillermo Jones in a cruiserweight bout at age 30. He was coming in with a record of 21-2 (17), and Jones was 33 years old and with a record of 32-3-2 (25). Braithwaite lost the fight via 4th-round TKO.
On April 2, 2005 Wayne Braithwaite, the WBC champion, met Jean-Marc Mormeck, the WBA (Super) and The Ring champion, in a cruiserweight world-title unification fight. Braithwaite was 29 years old and with a record of 21-1 (17), and Mormeck was 32 years old and with a record of 30-2 (21). Braithwaite lost the fight via 12-round unanimous decision and lost his title.