Vyacheslav Senchenko has two losses against two opponents on his boxing record. For a list of Senchenko's best fights, refer to "Best fights of Vyacheslav Senchenko".
On October 26, 2013 Vyacheslav Senchenko faced off against Kell Brook at age 36. He was coming in with a record of 34-2 (23), and Brook was 27 years old and with a record of 30-0 (20). Senchenko lost the fight via 4th-round TKO.
On April 29, 2012 Vyacheslav Senchenko met Paulie Malignaggi in a welterweight (WBA) world-title defense fight. Senchenko was 35 years old and with a record of 32-1 (21), and Malignaggi was 31 years old and with a record of 30-4 (6). Senchenko lost the fight via 9th-round TKO and lost the title.