Vitali Klitschko has two losses against two opponents on his boxing record. For a list of Klitschko's best fights, refer to "Best fights of Vitali Klitschko".
On June 21, 2003 Vitali Klitschko fought Lennox Lewis in a heavyweight world-title fight for Lewis' WBC and The Ring titles. Klitschko was 31 years old and with a record of 32-2 (31), and Lewis was 37 years old and with a record of 40-2-1 (31). Klitschko lost the fight via 6th-round TKO.
On April 1, 2000 Vitali Klitschko met Chris Byrd in a heavyweight (WBO) world-title defense fight. Klitschko was 28 years old and with a record of 27-1 (27), and Byrd was 29 years old and with a record of 30-1 (18). Klitschko lost the fight via 9th-round retirement and lost the title.