Vanes Martirosyan has four losses against four opponents on his boxing record. For a list of Martirosyan's best fights, refer to "Best fights of Vanes Martirosyan".
On May 5, 2018 Vanes Martirosyan fought Gennady Golovkin in a middleweight world-title fight for Golovkin's WBA (Super) and WBC titles. Martirosyan was 32 years old and with a record of 36-4-1 (21), and Golovkin was 36 years old and with a record of 37-0-1 (33). Martirosyan lost the fight via 2nd-round KO.
On May 21, 2016 Vanes Martirosyan fought Erislandy Lara in a super-welterweight world-title fight for Lara's WBA title. Martirosyan was 30 years old and with a record of 36-3-1 (21), and Lara was 33 years old and with a record of 22-2-2 (13). Martirosyan lost the fight via 12-round unanimous decision.
On March 28, 2015 Vanes Martirosyan faced off against Jermell Charlo at age 28. He was coming in with a record of 35-2-1 (21), and Charlo was 24 years old and with a record of 25-0 (11). Martirosyan lost the fight via 10-round unanimous decision.
On November 9, 2013 Vanes Martirosyan fought Demetrius Andrade in a super-welterweight world-title fight for the WBO title. Martirosyan was 27 years old and with a record of 33-1-1 (21), and Andrade was 25 years old and with a record of 19-0 (13). Martirosyan lost the fight via 12-round split decision.