Ulises Sierra has three losses against three opponents on his boxing record. For a list of Sierra's best fights, refer to "Best fights of Ulises Sierra".
On January 28, 2023 Ulises Sierra faced off against Bektemir Melikuziev in a super-middleweight bout at age 34. He was coming in with a record of 17-3-2 (10), and Melikuziev was 26 years old and with a record of 10-1 (8). Sierra lost the fight via 3rd-round KO.
On December 12, 2020 Ulises Sierra faced off against Edgar Berlanga at age 31. He was coming in with a record of 15-2-2 (9), and Berlanga was 23 years old and with a record of 15-0 (15). Sierra lost the fight via 1st-round TKO.
On January 17, 2020 Ulises Sierra faced off against Vladimir Shishkin at age 30. He was coming in with a record of 15-1-2 (9), and Shishkin was 28 years old and with a record of 9-0 (6). Sierra lost the fight via 10-round unanimous decision.