Oscar De La Hoya has six losses against five opponents on his boxing record. For a list of De La Hoya's best fights, refer to "Best fights of Oscar De La Hoya".
On December 6, 2008 Oscar De La Hoya faced off against Manny Pacquiao in a super-welterweight bout at age 35. He was coming in with a record of 39-6 (30), and Pacquiao was 29 years old and with a record of 47-3-2 (35). De La Hoya lost the fight via 8th-round retirement.
On May 5, 2007 Oscar De La Hoya met Floyd Mayweather Jr. in a super-welterweight (WBC) world-title defense fight. De La Hoya was 34 years old and with a record of 38-5 (30), and Mayweather Jr. was 30 years old and with a record of 37-0 (24). De La Hoya lost the fight via 12-round split decision and lost the title.
On September 18, 2004 Oscar De La Hoya, the WBO champion, met Bernard Hopkins, the WBA (Super), WBC, IBF and The Ring champion, in a middleweight world-title unification fight. De La Hoya was 31 years old and with a record of 37-4 (29), and Hopkins was 39 years old and with a record of 44-2-1 (31). De La Hoya lost the fight via 9th-round KO and lost his title.
On September 13, 2003 Oscar De La Hoya met Shane Mosley in a super-welterweight (WBA (Super), WBC, The Ring) world-title defense fight. De La Hoya was 30 years old and with a record of 36-3 (29), and Mosley was 32 years old and with a record of 38-2 (35). De La Hoya lost the fight via 12-round unanimous decision and lost the titles.
On June 17, 2000 Oscar De La Hoya fought Shane Mosley in a welterweight world-title fight for the WBC title. De La Hoya was 27 years old and with a record of 32-2 (26), and Mosley was 28 years old and with a record of 34-0 (32). De La Hoya lost the fight via 12-round split decision.
On September 18, 1999 Oscar De La Hoya, the WBC champion, met Félix Trinidad, the IBF champion, in a welterweight world-title unification fight. De La Hoya was 26 years old and with a record of 31-1 (25), and Trinidad was 26 years old and with a record of 35-0 (30). De La Hoya lost the fight via 12-round majority decision and lost his title.