Mike Perez has three losses against three opponents on his boxing record. For a list of Perez's best fights, refer to "Best fights of Mike Perez".
On September 30, 2017 Mike Perez fought Mairis Briedis in a cruiserweight world-title fight for Briedis' WBC title. Perez was 31 years old and with a record of 22-3-1 (14), and Briedis was 32 years old and with a record of 22-0 (18). Perez lost the fight via 12-round unanimous decision.
On May 22, 2015 Mike Perez faced off against Alexander Povetkin in a heavyweight bout at age 29. He was coming in with a record of 21-2-1 (13), and Povetkin was 35 years old and with a record of 28-1 (20). Perez lost the fight via 1st-round TKO.
On July 26, 2014 Mike Perez faced off against Bryant Jennings in a heavyweight bout at age 28. He was coming in with a record of 20-1-1 (12), and Jennings was 29 years old and with a record of 18-0 (10). Perez lost the fight via 12-round split decision.