Mikaela Mayer has two losses against two opponents on her boxing record. For a list of Mayer's best fights, refer to "Best fights of Mikaela Mayer".
On January 20, 2024 Mikaela Mayer fought Natasha Jonas in a welterweight world-title fight for Jonas' IBF title. Mayer was 33 years old and with a record of 19-2 (5), and Jonas was 39 years old and with a record of 14-2-1 (9). Mayer lost the fight via 10-round split decision.
On October 15, 2022 Mikaela Mayer, the WBO, IBF and The Ring champion, met Alycia Baumgardner, the WBC champion, in a super-featherweight world-title unification fight. Mayer was 32 years old and with a record of 17-1 (5), and Baumgardner was 28 years old and with a record of 12-1 (7). Mayer lost the fight via 10-round split decision and lost her titles.