Here is a list of Acosta's best fights. For a list of Acosta's losses, refer to "Miguel Acosta Losses".
On October 6, 2006 Miguel Acosta faced off against José Alfaro in a lightweight bout at age 28. He was coming in with a record of 18-3-2 (15), and Alfaro was 22 years old and with a record of 14-2 (13). Acosta won the fight via 10-round unanimous decision.
On July 25, 2009 Miguel Acosta fought Urbano Antillón in a lightweight world-title fight for Antillón's WBA title. Acosta was 31 years old and with a record of 26-3-2 (20), and Antillón was 26 years old and with a record of 26-0 (19). Acosta stopped Urbano Antillón via 9th-round TKO and is crowned the new lightweight world champion.
On May 29, 2010 Miguel Acosta fought Paulus Moses in a lightweight world-title fight for Moses' WBA title. Acosta was 32 years old and with a record of 27-3-2 (21), and Moses was 31 years old and with a record of 25-0 (17). Acosta stopped Paulus Moses via 6th-round KO and is crowned the new lightweight world champion.
On November 27, 2006 Miguel Acosta faced off against Gerardo Bermeo in a lightweight bout at age 28. He was coming in with a record of 19-3-2 (16). Acosta stopped Gerardo Bermeo via KO.