Marco Antonio Barrera has seven losses against five opponents on his boxing record. For a list of Barrera's best fights, refer to "Best fights of Marco Antonio Barrera".
On March 14, 2009 Marco Antonio Barrera faced off against Amir Khan in a lightweight bout at age 35. He was coming in with a record of 65-7 (43), and Khan was 22 years old and with a record of 19-1 (15). Barrera lost the fight via 5-round technical decision.
On October 6, 2007 Marco Antonio Barrera faced off against Manny Pacquiao in a super-featherweight bout at age 33. He was coming in with a record of 63-6 (42), and Pacquiao was 28 years old and with a record of 44-3-2 (34). Barrera lost the fight via 12-round unanimous decision.
On March 17, 2007 Marco Antonio Barrera met Juan Manuel Márquez in a super-featherweight (WBC) world-title defense fight. Barrera was 33 years old and with a record of 63-5 (42), and Márquez was 33 years old and with a record of 46-3-1 (35). Barrera lost the fight via 12-round unanimous decision and lost the title.
On November 15, 2003 Marco Antonio Barrera met Manny Pacquiao in a featherweight (The Ring) world-title defense fight. Barrera was 29 years old and with a record of 57-4 (40), and Pacquiao was 24 years old and with a record of 37-2-1 (28). Barrera lost the fight via 11th-round TKO and lost the title.
On February 19, 2000 Marco Antonio Barrera, the WBO champion, met Érik Morales, the WBC champion, in a super-bantamweight world-title unification fight. Barrera was 26 years old and with a record of 49-3 (36), and Morales was 23 years old and with a record of 35-0 (28). Barrera lost the fight via 12-round split decision and lost his title.
On April 18, 1997 Marco Antonio Barrera fought Junior Jones in a super-bantamweight world-title fight for Jones' WBO title. Barrera was 23 years old and with a record of 43-2 (31), and Jones was 26 years old and with a record of 43-2 (27). Barrera lost the fight via 12-round unanimous decision.
On November 22, 1996 Marco Antonio Barrera met Junior Jones in a super-bantamweight (WBO) world-title defense fight. Barrera was 22 years old and with a record of 43-1 (31), and Jones was 25 years old and with a record of 42-2 (26). Barrera lost the fight via 5th-round TKO and lost the title.