Luis Ortiz has three losses against two opponents on his boxing record. For a list of Ortiz's best fights, refer to "Best fights of Luis Ortiz".
On September 4, 2022 Luis Ortiz faced off against Andy Ruiz in a heavyweight bout at age 43. He was coming in with a record of 33-3 (28), and Ruiz was 32 years old and with a record of 34-2 (22). Ortiz lost the fight via 12-round unanimous decision.
On November 23, 2019 Luis Ortiz fought Deontay Wilder in a heavyweight world-title fight for Wilder's WBC title. Ortiz was 40 years old and with a record of 31-2 (26), and Wilder was 34 years old and with a record of 41-0-1 (40). Ortiz lost the fight via 7th-round KO.
On March 3, 2018 Luis Ortiz fought Deontay Wilder in a heavyweight world-title fight for Wilder's WBC title. Ortiz was 38 years old and with a record of 28-1 (24), and Wilder was 32 years old and with a record of 39-0 (38). Ortiz lost the fight via 10th-round TKO.
