Juan Manuel Márquez has seven losses against six opponents on his boxing record. For a list of Márquez's best fights, refer to "Best fights of Juan Manuel Márquez".
On October 12, 2013 Juan Manuel Márquez fought Timothy Bradley in a welterweight world-title fight for Bradley's WBO title. Márquez was 40 years old and with a record of 55-7-1 (40), and Bradley was 30 years old and with a record of 30-0 (12). Márquez lost the fight via 12-round split decision.
On November 12, 2011 Juan Manuel Márquez fought Manny Pacquiao in a welterweight world-title fight for Pacquiao's WBO title. Márquez was 38 years old and with a record of 53-6-1 (39), and Pacquiao was 32 years old and with a record of 53-3-2 (38). Márquez lost the fight via 12-round majority decision.
On September 19, 2009 Juan Manuel Márquez faced off against Floyd Mayweather Jr. in a lightweight bout at age 36. He was coming in with a record of 50-5-1 (37), and Mayweather Jr. was 32 years old and with a record of 39-0 (25). Márquez lost the fight via 12-round unanimous decision.
On March 15, 2008 Juan Manuel Márquez, the WBC champion, met Manny Pacquiao, the The Ring champion, in a super-featherweight world-title unification fight. Márquez was 34 years old and with a record of 48-4-1 (35), and Pacquiao was 29 years old and with a record of 45-3-2 (34). Márquez lost the fight via 12-round split decision and lost his title.
On March 4, 2006 Juan Manuel Márquez fought Chris John in a featherweight world-title fight for John's WBA title. Márquez was 32 years old and with a record of 44-3-1 (33), and John was 26 years old and with a record of 36-0-1 (20). Márquez lost the fight via 12-round unanimous decision.
On September 11, 1999 Juan Manuel Márquez fought Freddie Norwood in a featherweight world-title fight for Norwood's WBA title. Márquez was 26 years old and with a record of 29-2 (22), and Norwood was 29 years old and with a record of 35-0-1 (21). Márquez lost the fight via 12-round unanimous decision.
On May 29, 1993 Juan Manuel Márquez faced off against Javier Duran at age 19. He was coming in with a record of 0-1 (0). Márquez lost the fight via 1-round disqualification.