Jovanie Santiago has three losses against three opponents on his boxing record. For a list of Santiago's best fights, refer to "Best fights of Jovanie Santiago".
On February 11, 2023 Jovanie Santiago faced off against Mario Barrios in a super-lightweight bout at age 33. He was coming in with a record of 14-3-1 (10), and Barrios was 27 years old and with a record of 26-2 (17). Santiago lost the fight via 8th-round TKO.
On May 29, 2021 Jovanie Santiago faced off against Gary Antuanne Russell at age 31. He was coming in with a record of 14-2-1 (10), and Russell was 24 years old and with a record of 13-0 (13). Santiago lost the fight via 6th-round retirement.
On February 20, 2021 Jovanie Santiago faced off against Adrien Broner at age 31. He was coming in with a record of 14-1-1 (10), and Broner was 31 years old and with a record of 33-4-1 (24). Santiago lost the fight via 12-round unanimous decision.
