Here is a list of Lopez's best fights. For a list of Lopez's losses, refer to "Josesito Lopez Losses".
On June 23, 2012 Josesito Lopez faced off against Victor Ortiz in a welterweight bout at age 27. He was coming in with a record of 30-4 (18), and Ortiz was 25 years old and with a record of 29-3-2 (22). Lopez stopped Victor Ortiz via retirement.
On September 28, 2019 Josesito Lopez faced off against John Molina Jr. at age 35. He was coming in with a record of 37-8 (20), and Molina Jr. was 36 years old and with a record of 30-8 (24). Lopez stopped John Molina Jr. via TKO.