Joe Smith Jr. has five losses against five opponents on his boxing record. For a list of Smith Jr.'s best fights, refer to "Best fights of Joe Smith Jr.".
On October 7, 2023 Joe Smith Jr. faced off against Gilberto Ramírez in a cruiserweight bout at age 34. He was coming in with a record of 28-5 (22), and Ramírez was 32 years old and with a record of 44-1 (30). Smith Jr. lost the fight via 10-round unanimous decision.
On June 18, 2022 Joe Smith Jr., the WBO champion, met Artur Beterbiev, the WBC and IBF champion, in a light-heavyweight world-title unification fight. Smith Jr. was 32 years old and with a record of 28-4 (22), and Beterbiev was 37 years old and with a record of 17-0 (17). Smith Jr. lost the fight via 2nd-round TKO and lost his title.
On March 9, 2019 Joe Smith Jr. fought Dmitry Bivol in a light-heavyweight world-title fight for Bivol's WBA title. Smith Jr. was 29 years old and with a record of 24-3 (20), and Bivol was 28 years old and with a record of 15-0 (11). Smith Jr. lost the fight via 12-round unanimous decision.
On July 15, 2017 Joe Smith Jr. faced off against Sullivan Barrera in a light-heavyweight bout at age 27. He was coming in with a record of 23-2 (19), and Barrera was 35 years old and with a record of 19-1 (14). Smith Jr. lost the fight via 10-round unanimous decision.
On August 7, 2010 Joe Smith Jr. faced off against Eddie Caminero at age 20. He was coming in with a record of 6-1 (6). Smith Jr. lost the fight via 4th-round TKO.