Jessie Vargas has four losses against four opponents on his boxing record. For a list of Vargas's best fights, refer to "Best fights of Jessie Vargas".
On April 30, 2022 Jessie Vargas faced off against Liam Smith at age 32. He was coming in with a record of 29-4-2 (11), and Smith was 33 years old and with a record of 30-3-1 (17). Vargas lost the fight via 10th-round TKO.
On February 29, 2020 Jessie Vargas faced off against Mikey Garcia at age 30. He was coming in with a record of 29-3-2 (11), and Garcia was 32 years old and with a record of 39-1 (30). Vargas lost the fight via 12-round unanimous decision.
On November 5, 2016 Jessie Vargas met Manny Pacquiao in a welterweight (WBO) world-title defense fight. Vargas was 27 years old and with a record of 27-2 (10), and Pacquiao was 37 years old and with a record of 58-6-2 (38). Vargas lost the fight via 12-round unanimous decision and lost the title.
On June 27, 2015 Jessie Vargas fought Timothy Bradley in a welterweight world-title fight for the WBO title. Vargas was 26 years old and with a record of 26-1 (9), and Bradley was 31 years old and with a record of 31-1-1 (12). Vargas lost the fight via 12-round unanimous decision.
