Genaro Hernández has two losses against two opponents on his boxing record. For a list of Hernández's best fights, refer to "Best fights of Genaro Hernández".
On October 3, 1998 Genaro Hernández met Floyd Mayweather Jr. in a super-featherweight (WBC) world-title defense fight. Hernández was 32 years old and with a record of 38-2-1 (17), and Mayweather Jr. was 21 years old and with a record of 17-0 (13). Hernández lost the fight via 8th-round retirement and lost the title.
On September 9, 1995 Genaro Hernández fought Oscar De La Hoya in a lightweight world-title fight for De La Hoya's WBO title. Hernández was 29 years old and with a record of 32-1-1 (16), and De La Hoya was 22 years old and with a record of 18-0 (16). Hernández lost the fight via 6th-round retirement.